BLI Technology

Advanced label-free detection

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Biolayer Interferometry (BLI) is an advanced optical biosensing technique that enables real-time, label-free analysis of biomolecular interactions. By measuring changes in the interference pattern of white light reflected from a biosensor surface, BLI provides insights into binding events, including association and dissociation rates, without the need for fluorescent or radioactive labels.

hand holding tray of test tubes

OUR HISTORY

Origins and Evolution of BLI

Biolayer interferometry (BLI) was born from the need for a faster, simpler, and label-free way to study biomolecular interactions. Traditional methods were often complex, time-consuming, or limited in flexibility—leaving researchers searching for better solutions. In response, a new approach emerged: BLI provided real-time insights into binding events with unprecedented ease and versatility. Today, BLI continues to evolve, driven by a commitment to innovation that meets the growing demands of modern research—from antibodies to emerging modalities—helping scientists bring greater meaning to every molecule.

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Applications in Life Sciences

BLI has become an indispensable tool across multiple domains within the
life sciences:

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scientist works at a computer

Advantages of BLI

BLI offers several benefits that enhance its utility in research and development:

Applications

One platform. Endless possibilities.

From drug discovery and vaccine development to antibody characterization and quality control, Gator® Bio’s versatile BLI platform supports a wide range of applications across biopharma, academia, and diagnostics.

Looking Ahead

Impact on Life Sciences

The integration of BLI into research and development pipelines has significantly accelerated scientific discovery. Its ability to provide rapid, accurate, and detailed information about molecular interactions has transformed approaches in drug development, molecular biology, and biochemistry. By offering a user-friendly and efficient platform, BLI continues to empower scientists to unravel complex biological systems and develop innovative therapeutic solutions. 

Advancing the Future of BLI

At Gator Bio, we’re reimagining biolayer interferometry (BLI) to empower researchers and accelerate discovery. Building on the simplicity and speed that set BLI apart from traditional methods, we are pushing the boundaries of what’s possible with next-generation innovations. From seamless integration with lab automation for high-throughput screening to AI-driven biosensor design, our solutions are crafted to meet the evolving needs of modern science. Everything we do is guided by a single purpose: to help researchers unlock new insights, overcome challenges, and bring greater meaning to every molecule.

About Gator Bio

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WHAT OUR CUSTOMERS SAY

We have an antibody engineering department that reviews molecular candidates to generate different lead molecules. In terms of selecting BLI technology, it’s a really useful tool to screen [molecular] candidates and quickly create a selection to move forward. It’s a really useful tool for me and us.

Kyu Hong
 Associate director, bioanalysis
Immune-Onc Therapeutics

The Gator is now our lab’s most-used instrument. Its durability and versatility let us screen hundreds of samples, improving antigen affinity five- to six-fold. Compared to other systems, it offers a streamlined workflow, excels in high-throughput screening, and remains highly cost-effective, making it indispensable for our research.

Lei Chen CEO and Founder of Yikang Biotech (Suzhou)

The Gator has been a staple in our lab for six years. Its intuitive software, reliable data, and excellent value set it apart from Biacore and Octet. Ideal for quantitative antibody screening, affinity, and epitope analysis, its wide range of probes provides the flexibility needed for diverse experiments.

Louis Zhang Senior Scientist with over a decade of expertise in antibody discovery and development

…customer service was among the main reasons we chose to work with Gator as opposed to a competitor’s instrument, and I’m glad to see we were right in doing so!

Senior Scientist, Pharmaceutical Company

[Gator Bio] was extremely helpful, flexible, and professional, allowing onsite testing and extended instrument use for rigorous comparison with our existing BLI platform. [The FAS] impressed us with his knowledge and interpersonal skills – rare among vendor FAS. Our experience with Gator Bio has been far more positive, knowledgeable, and supportive than with [their] closest competitor.

Mauro Acchione, PhD Team Leader, Quality Attributes and Characterization, Human Health Therapeutics Research Center, National Research Council Canada