Small molecules. Big difference.

Small Molecule Analysis using BLI

Small molecules and peptide therapeutic drugs make up a large part of drug discovery and development. BLI provides a rapid label-free method for doing small molecule screening and characterization. Our SMAP biosensors enable detection of small molecules down to 150 Da with the binding partners.

The proprietary probe surface chemistry allows for high-capacity immobilization of biotinylated proteins for a wide range of molecular weights. Following immobilization, the ability of the biotinylated protein of interest to bind to small molecules can be measured to determine the kon, koff, and Kd of interaction. The interaction studies primarily performed on other fluidics-based techniques such as SPR can now be done using versatile BLI solution.


Benefits of Gator Bio Small Molecule Analysis


Fluidics-free instrumentation


Compatible with crude and purified samples


mM to pM affinity measurements

Specific Applications

  • Peptide: Protein interactions
  • Small molecule: Protein interaction
  • Enzyme: Small molecule
  • Structure-activity relationships
  • PROTAC analysis
Small Molecule Analysis

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